What is health information exchange (HIE) and how can we bridge the 'data islands' to improve the delivery and evaluation of health services? Health care data currently exists locked up in many different islands making data integration, exchange, and aggregation difficult. Bridges between these 'data islands' are needed, but how do we get everyone to speak or understand the same language? HIE and interoperability require standard data exchange formats and terminologies to promote understanding across systems. This course will provide an introduction to health information exchange, standardized data exchange formats and pharmacy terminologies, the pharmacy "Rosetta stone" RxNorm, and application of these topics, such as using RxNorm to identify medications of interest for health outcomes studies, especially when the products are off-patent and made by numerous manufacturers. Faculty will also discuss the use of common data models, such as the Observational Health Data Sciences and Informatics (OHDSI, ohdsi.org) collaborative research network. Participants will be encouraged to share their experiences and views, and will have opportunity to provide feedback and ask questions.