This course is designed to provide an introduction and overview of utility measures to support economic evaluations. The concepts of health-related quality of life and utility will be introduced and discussed in terms of their differences and similarities. Faculty will describe how these data can be combined with survival to estimate quality-adjusted life years. Some issues for debate will be introduced. In the second section, course participants will explore the methods that are used to capture utilities such as standard gamble, time trade off, and rating scales. Building on this will be a presentation of the different generic instruments that have been developed for measuring quality of life such as the EQ-5D, Health Utilities Index, and SF-36. Estimating utilities from a condition-specific measure will also be discussed. In the third section we will describe approaches that can be used when utility data from trials are not available. The development of mapping functions and other crosswalks will be described from disease-specific measures to generic HRQL measures. The pros and cons of the different main approaches will be discussed. Other approaches to addressing a lack of utility data will also be described including prospective observational studies, systematic reviews, critical appraisal of published values, and the valuation of vignette type descriptions of health. In the final section we will describe the requirements and preferences of different reimbursement agencies around the world including UK/Australia/Canada; US agencies; other EU markets such as Sweden/Belgium/Netherlands/Germany; Asia; and Latin America. The course will be interactive with break-out sessions and group discussion.