This course will provide an overview of various three health care databases including the Quintiles EMR database, the VA database, the CPRD (UK database) and assorted claims and survey based databases. Each database will be discussed in-depth including directions on how to access the information and how researchers utilize this data to generate information for health care decision making. Instructors will distinguish the important differences between these databases including the limitations and strategies to maximize their value through the use of an interactive assignments and workshops with the audience. The ISPOR International Digest of Databases and its use in identifying health care databases around the globe will be briefly discussed.